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 Conserved Domains and Protein Classification
 
 
 
How to find proteins with similar domain architectures
 
 

Any one of the methods below will retrieve proteins with similar domain architectures, which have been identified using the Conserved Domain Architecture Retrieval Tool (CDART):

 
  Method 1:   Use the CD-Search tool to compare a protein query sequence (either as raw sequence data in FASTA format, or as a GI or Accession) against the desired conserved domain data set, in order to identify functional units within the query sequence. Then press the "Search for similar domain architectures" button on the search results page. (See #1a and 1b in the example below.)   Thumbnail image showing the domain relatives for protein sequence NP_000240, human MutL protein homolog. Domain relatives are protein sequences that contain one or more of the conserved domains found in the query sequence, as identified by the Conserved Domain Architecture Retrieval Tool (CDART).  The large image at the bottom of this page provides a detailed example of how to find domain relatives for a query protein.  
 
  Method 2:   Retrieve a sequence record of interest from Entrez Protein database, open its "Links" menu, and select "Domain Relatives." (See #2 in the example below.)  
 
  Method 3:   Enter a protein query sequence (either as raw sequence data in FASTA format, or as a GI or Accession) directly on the Conserved Domain Architecture Retrieval Tool (CDART) page.  
 

Illustration showing how to find proteins with similar domain architectures, using NP_000240, the human MutL protein homolog 1, as an example query protein.

 
 
 
 
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