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Conserved domains on  [gi|50260954|gb|EAL23604|]
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hypothetical protein CNBA2510 [Cryptococcus neoformans var. neoformans B-3501A]

Protein Classification

type I methionyl aminopeptidase( domain architecture ID 10000257)

type I methionyl aminopeptidase (M24A family metallopeptidase) catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides

CATH:  3.90.230.10
EC:  3.4.11.18
MEROPS:  M24
PubMed:  7674922

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
88-323 2.77e-106

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 310.40  E-value: 2.77e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  88 GVRMACRVAADILKRAGhRIVKPGITTAQVDKAIHEMIIEHGAYPSPLGYSNYPKSCTTSINNVIVHGIPDNRPLHPQDI 167
Cdd:COG0024  11 KMREAGRIVAEVLDELA-EAVKPGVTTLELDRIAEEFIRDHGAIPAFLGYYGFPKSICTSVNEVVVHGIPSDRVLKDGDI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954 168 INIDLTIYLDGYHGDTSATFVLPEVDKLGRELVSATQEALDLGIRVCKPGVQISEIGKVIGEFSKRHGFSVNSQISGHGI 247
Cdd:COG0024  90 VNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGYSVVREFVGHGI 169
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 50260954 248 GKVFHQPPWIFHDVNSEPG-KMMPGDCFTIEPCLVQGvNSRGDIWDDGWTLATRTGARAAQFEHQVLITDDGVEILS 323
Cdd:COG0024 170 GREMHEEPQVPNYGRPGRGpRLKPGMVLAIEPMINAG-TPEVKVLDDGWTVVTKDGSLSAQFEHTVAVTEDGPEILT 245
 
Name Accession Description Interval E-value
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
88-323 2.77e-106

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 310.40  E-value: 2.77e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  88 GVRMACRVAADILKRAGhRIVKPGITTAQVDKAIHEMIIEHGAYPSPLGYSNYPKSCTTSINNVIVHGIPDNRPLHPQDI 167
Cdd:COG0024  11 KMREAGRIVAEVLDELA-EAVKPGVTTLELDRIAEEFIRDHGAIPAFLGYYGFPKSICTSVNEVVVHGIPSDRVLKDGDI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954 168 INIDLTIYLDGYHGDTSATFVLPEVDKLGRELVSATQEALDLGIRVCKPGVQISEIGKVIGEFSKRHGFSVNSQISGHGI 247
Cdd:COG0024  90 VNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGYSVVREFVGHGI 169
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 50260954 248 GKVFHQPPWIFHDVNSEPG-KMMPGDCFTIEPCLVQGvNSRGDIWDDGWTLATRTGARAAQFEHQVLITDDGVEILS 323
Cdd:COG0024 170 GREMHEEPQVPNYGRPGRGpRLKPGMVLAIEPMINAG-TPEVKVLDDGWTVVTKDGSLSAQFEHTVAVTEDGPEILT 245
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
88-323 9.07e-106

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 308.65  E-value: 9.07e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  88 GVRMACRVAADILKRAGhRIVKPGITTAQVDKAIHEMIIEHGAYPSPLGYSNYPKSCTTSINNVIVHGIPDNRPLHPQDI 167
Cdd:cd01086   3 GMREAGRIVAEVLDELA-KAIKPGVTTKELDQIAHEFIEEHGAYPAPLGYYGFPKSICTSVNEVVCHGIPDDRVLKDGDI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954 168 INIDLTIYLDGYHGDTSATFVLPEVDKLGRELVSATQEALDLGIRVCKPGVQISEIGKVIGEFSKRHGFSVNSQISGHGI 247
Cdd:cd01086  82 VNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGHGI 161
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 50260954 248 GKVFHQPPWIFHD-VNSEPGKMMPGDCFTIEPCLVQGvNSRGDIWDDGWTLATRTGARAAQFEHQVLITDDGVEILS 323
Cdd:cd01086 162 GRKFHEEPQIPNYgRPGTGPKLKPGMVFTIEPMINLG-TYEVVTLPDGWTVVTKDGSLSAQFEHTVLITEDGPEILT 237
PRK05716 PRK05716
methionine aminopeptidase; Validated
79-324 6.52e-98

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 289.34  E-value: 6.52e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954   79 IALGSKEEW-GVRMACRVAADILKRAGhRIVKPGITTAQVDKAIHEMIIEHGAYPSPLGYSNYPKSCTTSINNVIVHGIP 157
Cdd:PRK05716   3 ITIKTPEEIeKMRVAGRLAAEVLDEIE-PHVKPGVTTKELDRIAEEYIRDQGAIPAPLGYHGFPKSICTSVNEVVCHGIP 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  158 DNRPLHPQDIINIDLTIYLDGYHGDTSATFVLPEVDKLGRELVSATQEALDLGIRVCKPGVQISEIGKVIGEFSKRHGFS 237
Cdd:PRK05716  82 SDKVLKEGDIVNIDVTVIKDGYHGDTSRTFGVGEISPEDKRLCEVTKEALYLGIAAVKPGARLGDIGHAIQKYAEAEGFS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  238 VNSQISGHGIGKVFHQPPWIFHDVNSEPG-KMMPGDCFTIEPCLVQGvNSRGDIWDDGWTLATRTGARAAQFEHQVLITD 316
Cdd:PRK05716 162 VVREYCGHGIGRKFHEEPQIPHYGAPGDGpVLKEGMVFTIEPMINAG-KREVKTLKDGWTVVTKDGSLSAQYEHTVAVTE 240

                 ....*...
gi 50260954  317 DGVEILSI 324
Cdd:PRK05716 241 DGPEILTL 248
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
79-323 1.26e-77

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 237.63  E-value: 1.26e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954    79 IALGSKEEW-GVRMACRVAADILKRAgHRIVKPGITTAQVDKAIHEMIIEHGAYPSPLGYSNYPKSCTTSINNVIVHGIP 157
Cdd:TIGR00500   1 ISLKSPDEIeKIRKAGRLAAEVLEEL-EREVKPGVSTKELDRIAKDFIEKHGAKPAFLGYYGFPGSVCISVNEVVIHGIP 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954   158 DNRPLHPQDIINIDLTIYLDGYHGDTSATFVLPEVDKLGRELVSATQEALDLGIRVCKPGVQISEIGKVIGEFSKRHGFS 237
Cdd:TIGR00500  80 DKKVLKDGDIVNIDVGVIYDGYHGDTAKTFLVGKISPEAEKLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYAEAKGFS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954   238 VNSQISGHGIGKVFHQPPWIFH-DVNSEPGKMMPGDCFTIEPCLVQGvNSRGDIWDDGWTLATRTGARAAQFEHQVLITD 316
Cdd:TIGR00500 160 VVREYCGHGIGRKFHEEPQIPNyGKKFTNVRLKEGMVFTIEPMVNTG-TEEITTAADGWTVKTKDGSLSAQFEHTIVITD 238

                  ....*..
gi 50260954   317 DGVEILS 323
Cdd:TIGR00500 239 NGPEILT 245
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
92-316 7.96e-46

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 154.32  E-value: 7.96e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954    92 ACRVAADILKRAGHRIvKPGITTAQVDKAIH-EMIIEHGAypsplGYSNYPKSCTTSINNVIVHGIPDNRPLHPQDIINI 170
Cdd:pfam00557   6 AARIAAAALEAALAAI-RPGVTERELAAELEaARLRRGGA-----RGPAFPPIVASGPNAAIPHYIPNDRVLKPGDLVLI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954   171 DLTI-YLDGYHGDTSATFVLPEVDKLGRELVSATQEALDLGIRVCKPGVQISEIGKVIGEFSKRHGFSVNS-QISGHGIG 248
Cdd:pfam00557  80 DVGAeYDGGYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLGEYFpHGLGHGIG 159
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 50260954   249 KVFHQPPWIFHdvNSEPGKMMPGDCFTIEPclvqgvnsrGDIWDDGWtlatrtgaRAAQFEHQVLITD 316
Cdd:pfam00557 160 LEVHEGPYISR--GGDDRVLEPGMVFTIEP---------GIYFIPGW--------GGVRIEDTVLVTE 208
 
Name Accession Description Interval E-value
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
88-323 2.77e-106

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 310.40  E-value: 2.77e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  88 GVRMACRVAADILKRAGhRIVKPGITTAQVDKAIHEMIIEHGAYPSPLGYSNYPKSCTTSINNVIVHGIPDNRPLHPQDI 167
Cdd:COG0024  11 KMREAGRIVAEVLDELA-EAVKPGVTTLELDRIAEEFIRDHGAIPAFLGYYGFPKSICTSVNEVVVHGIPSDRVLKDGDI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954 168 INIDLTIYLDGYHGDTSATFVLPEVDKLGRELVSATQEALDLGIRVCKPGVQISEIGKVIGEFSKRHGFSVNSQISGHGI 247
Cdd:COG0024  90 VNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGYSVVREFVGHGI 169
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 50260954 248 GKVFHQPPWIFHDVNSEPG-KMMPGDCFTIEPCLVQGvNSRGDIWDDGWTLATRTGARAAQFEHQVLITDDGVEILS 323
Cdd:COG0024 170 GREMHEEPQVPNYGRPGRGpRLKPGMVLAIEPMINAG-TPEVKVLDDGWTVVTKDGSLSAQFEHTVAVTEDGPEILT 245
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
88-323 9.07e-106

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 308.65  E-value: 9.07e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  88 GVRMACRVAADILKRAGhRIVKPGITTAQVDKAIHEMIIEHGAYPSPLGYSNYPKSCTTSINNVIVHGIPDNRPLHPQDI 167
Cdd:cd01086   3 GMREAGRIVAEVLDELA-KAIKPGVTTKELDQIAHEFIEEHGAYPAPLGYYGFPKSICTSVNEVVCHGIPDDRVLKDGDI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954 168 INIDLTIYLDGYHGDTSATFVLPEVDKLGRELVSATQEALDLGIRVCKPGVQISEIGKVIGEFSKRHGFSVNSQISGHGI 247
Cdd:cd01086  82 VNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGHGI 161
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 50260954 248 GKVFHQPPWIFHD-VNSEPGKMMPGDCFTIEPCLVQGvNSRGDIWDDGWTLATRTGARAAQFEHQVLITDDGVEILS 323
Cdd:cd01086 162 GRKFHEEPQIPNYgRPGTGPKLKPGMVFTIEPMINLG-TYEVVTLPDGWTVVTKDGSLSAQFEHTVLITEDGPEILT 237
PRK05716 PRK05716
methionine aminopeptidase; Validated
79-324 6.52e-98

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 289.34  E-value: 6.52e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954   79 IALGSKEEW-GVRMACRVAADILKRAGhRIVKPGITTAQVDKAIHEMIIEHGAYPSPLGYSNYPKSCTTSINNVIVHGIP 157
Cdd:PRK05716   3 ITIKTPEEIeKMRVAGRLAAEVLDEIE-PHVKPGVTTKELDRIAEEYIRDQGAIPAPLGYHGFPKSICTSVNEVVCHGIP 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  158 DNRPLHPQDIINIDLTIYLDGYHGDTSATFVLPEVDKLGRELVSATQEALDLGIRVCKPGVQISEIGKVIGEFSKRHGFS 237
Cdd:PRK05716  82 SDKVLKEGDIVNIDVTVIKDGYHGDTSRTFGVGEISPEDKRLCEVTKEALYLGIAAVKPGARLGDIGHAIQKYAEAEGFS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  238 VNSQISGHGIGKVFHQPPWIFHDVNSEPG-KMMPGDCFTIEPCLVQGvNSRGDIWDDGWTLATRTGARAAQFEHQVLITD 316
Cdd:PRK05716 162 VVREYCGHGIGRKFHEEPQIPHYGAPGDGpVLKEGMVFTIEPMINAG-KREVKTLKDGWTVVTKDGSLSAQYEHTVAVTE 240

                 ....*...
gi 50260954  317 DGVEILSI 324
Cdd:PRK05716 241 DGPEILTL 248
PLN03158 PLN03158
methionine aminopeptidase; Provisional
41-323 3.36e-88

methionine aminopeptidase; Provisional


Pssm-ID: 215607 [Multi-domain]  Cd Length: 396  Bit Score: 269.78  E-value: 3.36e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954   41 VPDHIRRPQyvpinfftapWGEHNIPEMGVDNETEGARIALGSKEEWGVRMACRVAADILKRAGhRIVKPGITTAQVDKA 120
Cdd:PLN03158 108 VPDHIPKPD----------WALDGTPKIEPNSDLQHSVEIKTPEQIQRMRETCRIAREVLDAAA-RAIKPGVTTDEIDRV 176
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  121 IHEMIIEHGAYPSPLGYSNYPKSCTTSINNVIVHGIPDNRPLHPQDIINIDLTIYLDGYHGDTSATFVLPEVDKLGRELV 200
Cdd:PLN03158 177 VHEATIAAGGYPSPLNYHFFPKSCCTSVNEVICHGIPDARKLEDGDIVNVDVTVYYKGCHGDLNETFFVGNVDEASRQLV 256
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  201 SATQEALDLGIRVCKPGVQISEIGKVIGEFSKRHGFSVNSQISGHGIGKVFHQPPWIFHDV-NSEPGKMMPGDCFTIEPC 279
Cdd:PLN03158 257 KCTYECLEKAIAIVKPGVRYREVGEVINRHATMSGLSVVKSYCGHGIGELFHCAPNIPHYArNKAVGVMKAGQVFTIEPM 336
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 50260954  280 LVQGVnSRGDIWDDGWTLATRTGARAAQFEHQVLITDDGVEILS 323
Cdd:PLN03158 337 INAGV-WRDRMWPDGWTAVTADGKRSAQFEHTLLVTETGVEVLT 379
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
75-322 6.45e-86

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 259.00  E-value: 6.45e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954   75 EGARIALGSKEEW-GVRMACRVAADILKRAGhRIVKPGITTAQVDKAIHEMIIEHGAYPSPLGYSNYPKSCTTSINNVIV 153
Cdd:PRK12896   4 EGRGMEIKSPRELeKMRKIGRIVATALKEMG-KAVEPGMTTKELDRIAEKRLEEHGAIPSPEGYYGFPGSTCISVNEEVA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  154 HGIPDNRPLHPQDIINIDLTIYLDGYHGDTSATFVLPEVDKLGRELVSATQEALDLGIRVCKPGVQISEIGKVIGEFSKR 233
Cdd:PRK12896  83 HGIPGPRVIKDGDLVNIDVSAYLDGYHGDTGITFAVGPVSEEAEKLCRVAEEALWAGIKQVKAGRPLNDIGRAIEDFAKK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  234 HGFSVNSQISGHGIGKVFHQPPWIFH--DVNSEPGKMMPGDCFTIEPCLVQGVNSrGDIWDDGWTLATRTGARAAQFEHQ 311
Cdd:PRK12896 163 NGYSVVRDLTGHGVGRSLHEEPSVILtyTDPLPNRLLRPGMTLAVEPFLNLGAKD-AETLDDGWTVVTPDKSLSAQFEHT 241
                        250
                 ....*....|.
gi 50260954  312 VLITDDGVEIL 322
Cdd:PRK12896 242 VVVTRDGPEIL 252
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
79-323 1.26e-77

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 237.63  E-value: 1.26e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954    79 IALGSKEEW-GVRMACRVAADILKRAgHRIVKPGITTAQVDKAIHEMIIEHGAYPSPLGYSNYPKSCTTSINNVIVHGIP 157
Cdd:TIGR00500   1 ISLKSPDEIeKIRKAGRLAAEVLEEL-EREVKPGVSTKELDRIAKDFIEKHGAKPAFLGYYGFPGSVCISVNEVVIHGIP 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954   158 DNRPLHPQDIINIDLTIYLDGYHGDTSATFVLPEVDKLGRELVSATQEALDLGIRVCKPGVQISEIGKVIGEFSKRHGFS 237
Cdd:TIGR00500  80 DKKVLKDGDIVNIDVGVIYDGYHGDTAKTFLVGKISPEAEKLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYAEAKGFS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954   238 VNSQISGHGIGKVFHQPPWIFH-DVNSEPGKMMPGDCFTIEPCLVQGvNSRGDIWDDGWTLATRTGARAAQFEHQVLITD 316
Cdd:TIGR00500 160 VVREYCGHGIGRKFHEEPQIPNyGKKFTNVRLKEGMVFTIEPMVNTG-TEEITTAADGWTVKTKDGSLSAQFEHTIVITD 238

                  ....*..
gi 50260954   317 DGVEILS 323
Cdd:TIGR00500 239 NGPEILT 245
PRK12318 PRK12318
methionyl aminopeptidase;
88-324 2.02e-61

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 197.35  E-value: 2.02e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954   88 GVRMACRVAADILKrAGHRIVKPGITTAQVDKAIHEMIIEHGAYPSPLGYSN--YPKSCTTSINNVIVHGIPDNRPLHPQ 165
Cdd:PRK12318  51 KIRKACQVTARILD-ALCEAAKEGVTTNELDELSRELHKEYNAIPAPLNYGSppFPKTICTSLNEVICHGIPNDIPLKNG 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  166 DIINIDLTIYLDGYHGDTSATFVLPEVDKLGRELVSATQEALDLGIRVCKPGVQISEIGKVIGEFSKRHGFSVNSQISGH 245
Cdd:PRK12318 130 DIMNIDVSCIVDGYYGDCSRMVMIGEVSEIKKKVCQASLECLNAAIAILKPGIPLYEIGEVIENCADKYGFSVVDQFVGH 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  246 GIGKVFHQPPWIFHDVNSEPGKMMPGDCFTIEPCLvqGVNSRGDIWD--DGWTLATRTGARAAQFEHQVLITDDGVEILS 323
Cdd:PRK12318 210 GVGIKFHENPYVPHHRNSSKIPLAPGMIFTIEPMI--NVGKKEGVIDpiNHWEARTCDNQPSAQWEHTILITETGYEILT 287

                 .
gi 50260954  324 I 324
Cdd:PRK12318 288 L 288
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
92-316 7.96e-46

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 154.32  E-value: 7.96e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954    92 ACRVAADILKRAGHRIvKPGITTAQVDKAIH-EMIIEHGAypsplGYSNYPKSCTTSINNVIVHGIPDNRPLHPQDIINI 170
Cdd:pfam00557   6 AARIAAAALEAALAAI-RPGVTERELAAELEaARLRRGGA-----RGPAFPPIVASGPNAAIPHYIPNDRVLKPGDLVLI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954   171 DLTI-YLDGYHGDTSATFVLPEVDKLGRELVSATQEALDLGIRVCKPGVQISEIGKVIGEFSKRHGFSVNS-QISGHGIG 248
Cdd:pfam00557  80 DVGAeYDGGYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLGEYFpHGLGHGIG 159
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 50260954   249 KVFHQPPWIFHdvNSEPGKMMPGDCFTIEPclvqgvnsrGDIWDDGWtlatrtgaRAAQFEHQVLITD 316
Cdd:pfam00557 160 LEVHEGPYISR--GGDDRVLEPGMVFTIEP---------GIYFIPGW--------GGVRIEDTVLVTE 208
PRK12897 PRK12897
type I methionyl aminopeptidase;
106-323 9.84e-41

type I methionyl aminopeptidase;


Pssm-ID: 171806  Cd Length: 248  Bit Score: 142.48  E-value: 9.84e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  106 RIVKPGITTAQVDKAIHEMIIEHGAYPSPLGYSNYPKSCTTSINNVIVHGIPDNRPLHPQDIINIDLTIYLDGYHGDTSA 185
Cdd:PRK12897  29 KIMKPGITTKEINTFVEAYLEKHGATSEQKGYNGYPYAICASVNDEMCHAFPADVPLTEGDIVTIDMVVNLNGGLSDSAW 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  186 TFVLPEVDKLGRELVSATQEALDLGIRVCKPGVQISEIGKVIGEFSKRHGFSVNSQISGHGIGKVFHQPPWIFHDVNSEP 265
Cdd:PRK12897 109 TYRVGKVSDEAEKLLLVAENALYKGIDQAVIGNRVGDIGYAIESYVANEGFSVARDFTGHGIGKEIHEEPAIFHFGKQGQ 188
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  266 G-KMMPGDCFTIEPCLVQGVN-SRGDIwdDGWTLATRTGARAAQFEHQVLITDDGVEILS 323
Cdd:PRK12897 189 GpELQEGMVITIEPIVNVGMRySKVDL--NGWTARTMDGKLSAQYEHTIAITKDGPIILT 246
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
89-318 2.86e-32

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 119.10  E-value: 2.86e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  89 VRMACRVAADILKRAGHRIvKPGITTAQVDKAIHEMIIEHGAYPSPLGYsnypksCTTSINNVIVHGIPDNRPLHPQDII 168
Cdd:cd01066   4 LRKAAEIAEAAMAAAAEAI-RPGVTEAEVAAAIEQALRAAGGYPAGPTI------VGSGARTALPHYRPDDRRLQEGDLV 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954 169 NIDLTIYLDGYHGDTSATFVLPEVDKLGRELVSATQEALDLGIRVCKPGVQISEIGKVIGEFSKRHGFSVNSQ-ISGHGI 247
Cdd:cd01066  77 LVDLGGVYDGYHADLTRTFVIGEPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREVLEEHGLGPNFGhRTGHGI 156
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 50260954 248 GKVFHQPPWIFHDvnsEPGKMMPGDCFTIEPclvqgvnsrgdiwddGWTLATRTGARaaqFEHQVLITDDG 318
Cdd:cd01066 157 GLEIHEPPVLKAG---DDTVLEPGMVFAVEP---------------GLYLPGGGGVR---IEDTVLVTEDG 206
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
83-323 1.52e-28

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 111.84  E-value: 1.52e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  83 SKEEW-GVRMACRVAADILKRAgHRIVKPGITTAQVDKAIHEMIIEHGAYpsplgYSNYPKSCTTSINNVIVHGIPDNRP 161
Cdd:COG0006  75 SPEEIeLMRKAARIADAAHEAA-LAALRPGVTEREVAAELEAAMRRRGAE-----GPSFDTIVASGENAAIPHYTPTDRP 148
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954 162 LHPQDIINIDLTIYLDGYHGDTSATFVLPEVDKLGRELVSATQEALDLGIRVCKPGVQISEIGKVIGEFSKRHGFS---V 238
Cdd:COG0006 149 LKPGDLVLIDAGAEYDGYTSDITRTVAVGEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAARDVLAEAGYGeyfP 228
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954 239 NSQisGHGIGKVFHQPPWIFHDvnsEPGKMMPGDCFTIEPclvqGvnsrgdIWDDGWtlatrTGARAaqfEHQVLITDDG 318
Cdd:COG0006 229 HGT--GHGVGLDVHEGPQISPG---NDRPLEPGMVFTIEP----G------IYIPGI-----GGVRI---EDTVLVTEDG 285

                ....*
gi 50260954 319 VEILS 323
Cdd:COG0006 286 AEVLT 290
MetAP2 cd01088
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
94-296 2.25e-26

Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238521 [Multi-domain]  Cd Length: 291  Bit Score: 105.80  E-value: 2.25e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  94 RVAADILKRA---GHRIVKPGITTAQVDKAIHEMIIEHGAYPSplgysnYPksCTTSINNVIVHGIP---DNRPLHPQDI 167
Cdd:cd01088   5 REAGEIHRQVrkyAQSLIKPGMTLLEIAEFVENRIRELGAGPA------FP--VNLSINECAAHYTPnagDDTVLKEGDV 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954 168 INIDLTIYLDGYHGDTSATFvlpEVDKLGRELVSATQEALDLGIRVCKPGVQISEIGKVIGEFSKRHGFSVNSQISGHGI 247
Cdd:cd01088  77 VKLDFGAHVDGYIADSAFTV---DFDPKYDDLLEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIESYGFKPIRNLTGHSI 153
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 50260954 248 GkvfhqpPWIFHDVNSEP-------GKMMPGDCFTIEPClvqGVNSRGDIWDDGWT 296
Cdd:cd01088 154 E------RYRLHAGKSIPnvkggegTRLEEGDVYAIEPF---ATTGKGYVHDGPEC 200
PRK07281 PRK07281
methionyl aminopeptidase;
107-323 6.20e-22

methionyl aminopeptidase;


Pssm-ID: 180918  Cd Length: 286  Bit Score: 93.37  E-value: 6.20e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  107 IVKPGITTAQVDKAIHEMIIEHGAYPSPLG----YSNYPKSCTTSINNVIVHGIPDNRPLHPQDIINIDLTI-------- 174
Cdd:PRK07281  30 LIKPGVDMWEVEEYVRRRCKEENVLPLQIGvdgaMMDYPYATCCGLNDEVAHAFPRHYILKEGDLLKVDMVLsepldksi 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  175 ----------------YLDGYHG---DTSATFVLPEVDKLGRELVSATQEALDLGIRVCKPGVQISEIGKVIGEFSKRHG 235
Cdd:PRK07281 110 vdvsklnfdnveqmkkYTESYRGglaDSCWAYAVGTPSDEVKNLMDVTKEAMYRGIEQAVVGNRIGDIGAAIQEYAESRG 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  236 FSVNSQISGHGIGKVFHQPPWIFHDVNSEPG-KMMPGDCFTIEPCLVQGVNSRGDIWDDGWTLATRTGARAAQFEHQVLI 314
Cdd:PRK07281 190 YGVVRDLVGHGVGPTMHEEPMVPNYGTAGRGlRLREGMVLTIEPMINTGTWEIDTDMKTGWAHKTLDGGLSCQYEHQFVI 269

                 ....*....
gi 50260954  315 TDDGVEILS 323
Cdd:PRK07281 270 TKDGPVILT 278
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
88-278 1.29e-21

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 90.65  E-value: 1.29e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  88 GVRMACRVAADILKraghrIVKPGITTAQVDKAIHEMIIEHGAYpsplGYSnYPKSCTTSINNVIVHGIPDNRPLHPQDI 167
Cdd:cd01092   7 AARIADKAFEELLE-----FIKPGMTEREVAAELEYFMRKLGAE----GPS-FDTIVASGPNSALPHGVPSDRKIEEGDL 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954 168 INIDLTIYLDGYHGDTSATFVLPEVDKLGRELVSATQEALDLGIRVCKPGVQISEIGKVIGEFSKRHGFS---VNSqiSG 244
Cdd:cd01092  77 VLIDFGAIYDGYCSDITRTVAVGEPSDELKEIYEIVLEAQQAAIKAVKPGVTAKEVDKAARDVIEEAGYGeyfIHR--TG 154
                       170       180       190
                ....*....|....*....|....*....|....
gi 50260954 245 HGIGKVFHQPPWIfhdVNSEPGKMMPGDCFTIEP 278
Cdd:cd01092 155 HGVGLEVHEAPYI---SPGSDDVLEEGMVFTIEP 185
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
94-294 1.06e-12

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 68.20  E-value: 1.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954   94 RVAADILK---RAGHRIVKPGIT----TAQVDKAIHEMIIEHGAYPsplGYSnYPKSCttSINNVIVHGIP---DNRPLH 163
Cdd:PTZ00053 162 RRAAEVHRqvrRYAQSVIKPGVKlidiCERIESKSRELIEADGLKC---GWA-FPTGC--SLNHCAAHYTPntgDKTVLT 235
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  164 PQDIINIDLTIYLDGYHGDTSATFVL-PEVDKLgrelVSATQEALDLGIRVCKPGVQISEIGKVIGEFSKRHGFSVNSQI 242
Cdd:PTZ00053 236 YDDVCKLDFGTHVNGRIIDCAFTVAFnPKYDPL----LQATKDATNTGIKEAGIDVRLSDIGAAIQEVIESYEVEIKGKT 311
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 50260954  243 ---------SGHGIGkvfhqpPWIFHDVNSEP-------GKMMPGDCFTIEpclVQGVNSRGDIWDDG 294
Cdd:PTZ00053 312 ypiksirnlNGHSIG------PYIIHGGKSVPivkggenTRMEEGELFAIE---TFASTGRGYVNEDL 370
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
90-323 8.11e-10

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 58.35  E-value: 8.11e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  90 RMACRVAADILKRAgHRIVKPGITTAQVDKAIHEMIIEHGAYPSplgysnYPKSCTTSINNVIVHGIPDNRPLHPQDIIN 169
Cdd:cd01087   5 RKACDISAEAHRAA-MKASRPGMSEYELEAEFEYEFRSRGARLA------YSYIVAAGSNAAILHYVHNDQPLKDGDLVL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954 170 IDLTIYLDGYHGDTSATF-VLPEVDKLGRELVSATQEALDLGIRVCKPGVQISEI----GKVIGEFSKRHGF---SVNSQ 241
Cdd:cd01087  78 IDAGAEYGGYASDITRTFpVNGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIhllaHRVLAEGLKELGIlkgDVDEI 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954 242 ISG--------HGIGkvfHqppWI---FHDV------NSEPGKMMPGDCFTIEPclvqGV-NSRGDIWDDgwtlatrtga 303
Cdd:cd01087 158 VESgayakffpHGLG---H---YLgldVHDVggylryLRRARPLEPGMVITIEP----GIyFIPDLLDVP---------- 217
                       250       260
                ....*....|....*....|....*
gi 50260954 304 RAAQF-----EHQVLITDDGVEILS 323
Cdd:cd01087 218 EYFRGggiriEDDVLVTEDGPENLT 242
PA2G4-like cd01089
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family ...
94-323 1.57e-07

Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.


Pssm-ID: 238522  Cd Length: 228  Bit Score: 51.18  E-value: 1.57e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  94 RVAADILKRAGHRIV---KPGITTAQV----DKAIHEMI---------IEHG-AYPSplgysnypkscTTSINNVIVHGI 156
Cdd:cd01089   5 KTAGQIANKVLKQVIslcVPGAKVVDLcekgDKLILEELgkvykkekkLEKGiAFPT-----------CISVNNCVCHFS 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954 157 P----DNRPLHPQDIINIDLTIYLDGYHGDTSATFVLPEVD---KLGR--ELVSATQEALDLGIRVCKPGVQISEIGKVI 227
Cdd:cd01089  74 PlksdATYTLKDGDVVKIDLGCHIDGYIAVVAHTIVVGAEAetpVTGKkaDVIAAAHYALEAALRLLRPGNQNSDITEAI 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954 228 GEFSKRHGF-SVNSQISghgigkvfHQPPWifhDVNSEPGKMMPGDCftiepclvqgvnSRGDIWDDGWTLATRTGARAA 306
Cdd:cd01089 154 QKVIVDYGCtPVEGVLS--------HQLKR---VVSSGEGKAKLVEC------------VKHGLLFPYPVLYEKEGEVVA 210
                       250
                ....*....|....*..
gi 50260954 307 QFEHQVLITDDGVEILS 323
Cdd:cd01089 211 QFKLTVLLTPNGVTVLT 227
PRK14576 PRK14576
putative endopeptidase; Provisional
156-323 3.49e-05

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 45.01  E-value: 3.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  156 IPDNRPLHPQDIINIDLTIYLDGYHGDTSATFVLPEVDKLGRELVSATQEALDLGIRVCKPGVQISEIGKVIGEFSKRHG 235
Cdd:PRK14576 246 IADTTPAKVGDLIKFDCGIDVAGYGADLARTFVLGEPDKLTQQIYDTIRTGHEHMLSMVAPGVKLKAVFDSTMAVIKTSG 325
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  236 FS-VNSQISGHGIGkVF---HQPPWIFHDVNSepgKMMPGDCFTIEpclvqgvnsrgdiwddgwTLATRTGARAAQFEHQ 311
Cdd:PRK14576 326 LPhYNRGHLGHGDG-VFlglEEVPFVSTQATE---TFCPGMVLSLE------------------TPYYGIGVGSIMLEDM 383
                        170
                 ....*....|..
gi 50260954  312 VLITDDGVEILS 323
Cdd:PRK14576 384 ILITDSGFEFLS 395
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
83-223 5.43e-05

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 44.72  E-value: 5.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954   83 SKEEWGV-RMACRVAADILKRAGHRiVKPGITTAQVDKAIHEMIIEHGA-YPSplgysnYPKSCTTSINNVIVHGIPDNR 160
Cdd:PRK10879 175 SPEEIAVlRRAGEISALAHTRAMEK-CRPGMFEYQLEGEIHHEFNRHGArYPS------YNTIVGSGENGCILHYTENES 247
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 50260954  161 PLHPQDIINIDLTIYLDGYHGDTSATF-VLPEVDKLGRELVSATQEALDLGIRVCKPGVQISEI 223
Cdd:PRK10879 248 EMRDGDLVLIDAGCEYKGYAGDITRTFpVNGKFTPAQREIYDIVLESLETSLRLYRPGTSIREV 311
PRK15173 PRK15173
peptidase; Provisional
156-248 2.18e-04

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 42.40  E-value: 2.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  156 IPDNRPLHPQDIINIDLTIYLDGYHGDTSATFVLPEVDKLGRELVSATQEALDLGIRVCKPGVQISEIGKVIGEFSKRHG 235
Cdd:PRK15173 164 IPSNTKACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDSTMEVIKKSG 243
                         90
                 ....*....|....
gi 50260954  236 F-SVNSQISGHGIG 248
Cdd:PRK15173 244 LpNYNRGHLGHGNG 257
PRK14575 PRK14575
putative peptidase; Provisional
156-248 3.14e-04

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 42.00  E-value: 3.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954  156 IPDNRPLHPQDIINIDLTIYLDGYHGDTSATFVLPEVDKLGRELVSATQEALDLGIRVCKPGVQISEIGKVIGEFSKRHG 235
Cdd:PRK14575 247 IPSNTKACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDSTMEVIKKSG 326
                         90
                 ....*....|....
gi 50260954  236 F-SVNSQISGHGIG 248
Cdd:PRK14575 327 LpNYNRGHLGHGNG 340
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
147-245 6.08e-04

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 41.03  E-value: 6.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50260954   147 SINNVIVHGIP----DNRPLHPQDIINIDLTIYLDGYHGDTSATFVL---PEVDKLGR--ELVSATQEALDLGIRVCKPG 217
Cdd:TIGR00495  83 SVNNCVGHFSPlksdQDYILKEGDVVKIDLGCHIDGFIALVAHTFVVgvaQEEPVTGRkaDVIAAAHLAAEAALRLVKPG 162
                          90       100
                  ....*....|....*....|....*...
gi 50260954   218 VQISEIGKVIGEFSKRHGFSVNSQISGH 245
Cdd:TIGR00495 163 NTNTQVTEAINKVAHSYGCTPVEGMLSH 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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