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chloride channel protein

ClC family voltage-gated chloride channel protein containing a C-terminal CBS pair domain, catalyzes the selective flow of Cl(-) ions across the cellular membrane

Arch. IDVersionDate PublishedReview Level
1008705832022-09-13
curated
Arch. ID10087058
Version3
Date Published2022-09-13
Review Level
curated
Voltage_gated_ClC: CLC voltage-gated chloride channelVoltage_gated_ClCCBS_pair_SF: Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamilyCBS_pair_SF
SCOP:  4003598
CATH:  1.10.3080.10
Gene Ontology:  GO:0006821 | GO:0005247
PubMed:  11182894
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Sequences with this architecture
Name, label and taxonomic scope
Taxonomic scopeNameLabel
All organismschloride channel proteinClC family voltage-gated chloride channel protein containing a C-terminal CBS pair domain, catalyzes the selective flow of Cl(-) ions across the cellular membrane
Name, label and taxonomic scope
Tax. ExpAll organisms
Namechloride channel protein
LabelClC family voltage-gated chloride channel protein containing a C-terminal CBS pair domain, catalyzes the selective flow of Cl(-) ions across the cellular membrane
Supporting evidence
CDD
  • cd00400: Voltage_gated_ClC : CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective...
  • cd04613: CBS_pair_voltage-gated_CLC_bac : Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in bacteria
Protein Accession
  • KXK25683: chloride channel protein [Candidatus Brocadia sinica]
Publications
Conserved domains in this architecture
AccessionShort nameTitle
cd00400Voltage_gated_ClCCLC voltage-gated chloride channel
cl15354CBS_pair_SFTwo tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily
Functional sites in this architecture
TitleTypeSource domain
Cl- selectivity filteractivecd00400
pore gating glutamate residueactivecd00400
Cl- binding residuesion bindingcd00400
dimer interfacepolypeptide bindingcd00400

    HHS Vulnerability Disclosure