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DNA topoisomerase subunit B

DNA topoisomerase subunit B relaxes positive DNA supercoils generated during DNA replication; such as Staphylococcus aureus DNA topoisomerase IV subunit B and Bacillus subtilis DNA gyrase subunit B

Arch. IDVersionDate PublishedReview Level
1148134822022-08-18
curated
Arch. ID11481348
Version2
Date Published2022-08-18
Review Level
curated
gyrB: DNA gyrase subunit BgyrB
EC:  5.6.2.2
Gene Ontology:  GO:0003918 | GO:0006265 | GO:0003677 | GO:0005524
PubMed:  11395412
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Sequences with this architecture
Name, label and taxonomic scope
Taxonomic scopeNameLabel
All organismsDNA topoisomerase subunit BDNA topoisomerase subunit B relaxes positive DNA supercoils generated during DNA replication; such as Staphylococcus aureus DNA topoisomerase IV subunit B and Bacillus subtilis DNA gyrase subunit B
Name, label and taxonomic scope
Tax. ExpAll organisms
NameDNA topoisomerase subunit B
LabelDNA topoisomerase subunit B relaxes positive DNA supercoils generated during DNA replication; such as Staphylococcus aureus DNA topoisomerase IV subunit B and Bacillus subtilis DNA gyrase subunit B
Supporting evidence
Comments
  • members include DNA topoisomerase IV subunit B and gyrase subunit B
  • DNA topoisomerases are divided into two classes: type I enzymes (EC:5.99.1.2; topoisomerases I, III and V) break single-strand DNA, and type II enzymes (EC:5.99.1.3; topoisomerases II, IV and VI) break double-strand DNA; Type II topoisomerases are ATP-dependent enzymes and can be subdivided according to their structure and reaction mechanisms: type IIA (topoisomerase II or gyrase, and topoisomerase IV) and type IIB (topoisomerase VI). These enzymes are responsible for relaxing supercoiled DNA as well as for introducing both negative and positive supercoils
E.C. Number
CDD
  • PRK05644: gyrB : DNA gyrase subunit B; Validated
Protein Accession
  • Q2FYS5: RecName: Full=DNA topoisomerase 4 subunit B; AltName: Full=Topoisomerase IV subunit B
  • Q59533: RecName: Full=DNA gyrase subunit B
  • AOR22228: type IIA DNA topoisomerase subunit B [Clostridium taeniosporum]
Publications
  • PMID 24126580: Optimization of pyrrolamides as mycobacterial GyrB ATPase inhibitors: structure-activity relationship and in vivo efficacy in a mouse model of tuberculosis.
  • PMID 11395412: DNA topoisomerases: structure, function, and mechanism.
Gene IDs
Conserved domains in this architecture
AccessionShort nameTitle
PRK05644gyrBDNA gyrase subunit B

    HHS Vulnerability Disclosure