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retinal guanylyl cyclase 2

retinal guanylyl cyclase 2 may play a specific role in rods and/or cones of photoreceptors, its activity appears modulated by the calmodulin-like Ca(2+)-binding protein GCAP2

Arch. IDVersionDate PublishedReview Level
1157090132023-08-22
curated
Arch. ID11570901
Version3
Date Published2023-08-22
Review Level
curated
PBP1_sensory_GC_DEF-like: ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissuesPBP1_sensory_GC_DEF-likeProtein Kinases, catalytic domain: The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases, and choline kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to hydroxyl groups in specific substrates such as serine, threonine, or tyrosine residues of proteins.Protein Kinases, catalytic domainHNOBA: Heme NO binding associatedHNOBACYCc: Adenylyl- / guanylyl cyclase, catalytic domainCYCc
EC:  4.6.1.2
PubMed:  7831337
Gene Ontology:  GO:0005524 | GO:0005525 | GO:0004383 | GO:0004672 | GO:0038023 | GO:0050908 | GO:0005886
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Sequences with this architecture
Name, label and taxonomic scope
Taxonomic scopeNameLabel
Metazoaretinal guanylyl cyclase 2retinal guanylyl cyclase 2 may play a specific role in rods and/or cones of photoreceptors, its activity appears modulated by the calmodulin-like Ca(2+)-binding protein GCAP2
Name, label and taxonomic scope
Tax. ExpMetazoa
Nameretinal guanylyl cyclase 2
Labelretinal guanylyl cyclase 2 may play a specific role in rods and/or cones of photoreceptors, its activity appears modulated by the calmodulin-like Ca(2+)-binding protein GCAP2
Supporting evidence
Comments
  • from 10157185: also called RETGC-2, guanylate cyclase 2F, retinal, guanylate cyclase F, GC-F, rod outer segment membrane guanylate cyclase 2, or ROS-GC2
E.C. Number
Protein Accession
  • P51841: RecName: Full=Retinal guanylyl cyclase 2; Short=RETGC-2; AltName: Full=Guanylate cyclase 2F, retinal; AltName: Full=Guanylate cyclase F; Short=GC-F; AltName: Full=Rod outer segment membrane guanylate cyclase 2; Short=ROS-GC2; Flags: Precursor
CDD
  • cd06371: PBP1_sensory_GC_DEF_like : Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
  • cd07302: CHD : cyclase homology domain
Publications
  • PMID 7777544: Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2.
  • PMID 7831337: Two membrane forms of guanylyl cyclase found in the eye.
  • PMID 9175772: Structural and functional characterization of a second subfamily member of the calcium-modulated bovine rod outer segment membrane guanylate cyclase, ROS-GC2.
Conserved domains in this architecture
AccessionShort nameTitle
cd06371PBP1_sensory_GC_DEF-likeligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
cl06648HNOBAHeme NO binding associated
cl21453Protein Kinases, catalytic domainThe protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases, and choline kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to hydroxyl groups in specific substrates such as serine, threonine, or tyrosine residues of proteins.
smart00044CYCcAdenylyl- / guanylyl cyclase, catalytic domain
Functional sites in this architecture
TitleTypeSource domain
putative ligand binding sitechemical bindingcd06371
putative Cl binding siteion bindingcd06371
putative dimer interface (closed form)polypeptide bindingcd06371
putative dimer interface (open form)polypeptide bindingcd06371

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