The FLink tool has been retired. Please consider using the Entrez Utility (EUtilties) to create your own scripting solution https://www.ncbi.nlm.nih.gov/books/NBK25501.

 FLink
 
 
 
What's New
 

To receive e-mail news about changes to FLink icon FLink, subscribe to the biosystems-announce@ncbi.nlm.nih.gov mailing list by completing a brief form or sending an e-mail message with the word subscribe in the subject line to biosystems-announce-request@ncbi.nlm.nih.gov.

 
 

New FLink function: gene expression data → ranked list of pathways

[15 MAR 2011]  Gene expression data in the GEO Profiles database now link to associated records in the BioSystems database. A Find pathways button on the GEO Profiles search results page will automatically perform a multiple step FLink icon FLink operation that retrieves pathways containing one or more of the genes represented in the expression data. The pathways can be ranked by frequency (illustrated example) or percent (%) coverage (illustrated example). More about FLink's ranking methods...

 
 

New FLink feature: rank hits by percent (%) coverage

[15 MAR 2011]  FLink icon FLink ranks hits from a destination database according to frequency, by default. Now, an alternative ranking method of percent (%) coverage is available for select destination databases such as BioSystems. It is an indicator of the degree to which your input list covers the scope of each retrieved record. For example, if 12 GeneIDs (from your input list of N genes) are linked to a particular biosystem record, and if that biosystem record has links to a total of 48 GeneIDs in the Entrez Gene database, then the percent coverage of that biosystem record by your input list will be 25%. More about FLink's ranking methods...

 
 
 
Supported Databases
 
 
  BioSystems
  Conserved Domain Database (CDD)
  Gene
  Protein
  PubChem BioAssay
  PubChem Compound
  PubChem Substance
  PubMed
  Structure
 
 
Any one of these can be used as a source database or destination database if you start on the FLink icon FLink home page and input a UID list directly into the tool. The types of data you can retrieve (as frequency-weighted lists) via FLink depend on which database you started in and are represented as Link Names in FLink's LinkTo dialog box.
 

 
News Archive
 
 

Public release of FLink

[29 JUL 2010]  FLink icon FLink is now publicly available. Developed to handle large quantities of input and output data, it is a tool that enables you to traverse from a group of records in a source database to a ranked list of associated records in a destination database. For example, it can accept up to 100,000 protein sequence, gene, or small molecule identifiers as input and retrieve a ranked list of up to 100,000 biosystems. An illustrated quick start guide shows the easy 1-2-3 step process for using the tool. The help document also provides details about the proper formatting of the (1) input UID list, the features of the (2) review + select display and (3) output display, and a list of supported databases.

 
 
Revised 7 December 2021